A study on mechanism of intestinal phosphate transport using everted gut sacs of mice
Background & objective: The transcellular transport of phosphate from the intestinal lumen to the blood requires • Phosphate uptake across the brush border of the enterocyte • Its sojourn through the cytoplasm and • Its exit across the basolateral membrane. The rate-limiting step and the main energy driving part of absorption is first step. Extensive studies are carried out on the luminal phosphate uptake but not on the exit process of phosphate from the cell.