Survey of medicinal plants was taken in Rajarajan Manimandapam, Thanjavur district. It is one of the famous refreshment centres for urban people. Here, museum and children’s play materials are maintained. Many plants are seen here which are protected for medicinal and ornamental purposes. The investigation revealed that 50 plant species are commonly used in the treatment of various diseases. The collected medicinal plants have been arranged alphabetically according to their botanical names, followed by their common names, family and the part which is used for medicinal purposes. Most of the plant species are used to cure common diseases like stomach pain, head ache, skin diseases, fever, ulcer etc., Even some of the plants possess anticancer property.