The present study aimed at the analysis of sensitivity of E. Coli and Klebsiella to the plant extracts of Adhatoda vasica and Leucas aspera. The ethanolic extract of these two medicinal plants traditionally used in medicine, were studied for their antibacterial activity against the common human pathogens. Both the medicinal plant extracts showed inhibitory activity against the bacteriae. The study comes to the conclusion that medicinal plants which are traditionally used in Ayurveda or in other herbal medical practices have scientific basics and can be modified to produce specific medicines against each bacterium.