For decades physicians and dentists are paying their concentrations in their own respective fields specializing in medical sciences pertaining to the body and oral cavity respectively. Oral health may be an indicator of systemic health. Many studies have discussed about the relationship between periodontal disease and systemic disease and because of this relationship the allopathic medicine and the dental medicine is quickly closing. Among the systemic diseases cardiovascular disease, diabetes mellitus, pregnancy outcomes, osteoporosis, Alzheimer’s disease and pre-term delivery have been associated with periodontal diseases. Researchers must continue to scratch more information regarding the correlations between the periodontal disease and systemic conditions. This review is an attempt to bring all the possible relations between periodontal diseases and systemic conditions.