This report is based on the findings from a captive reticulated python aged around eight years weighing 52 kilograms and 5.9 feet in length showed history of dullness, depression and a large sized bright red colored soiled mass hanging outside the vent. On detailed examination, the everted mass was identified as cloaca and the condition was called as cloacal prolapse. Cloacopexy was performed. The treatment and prevention methods were discussed.