Background: Diabetes mellitus is a major health problem that is associated with psychological, as well as physical, complications, particularly depression. Depression and diabetes are associated with dysfunction of the hypothalamic – pituitary adrenal (HPA) axis, which manifests as subclinical, hypercortisolism, blunted diurnal cortisol rhythm or hypercortisolism with impaired glucocorticoid sensitivity and increased inflammation. Aim: The aim of the study is to assess the depression and glycemic control among patients with diabetes mellitus. Methods: A cross-sectional study consists of 200 diabetes mellitus patients. Data were collected by using Hamilton Depression Rating Scale and observational checklist. Results: A sample of 200 diabetes mellitus patients were included in the study, the prevalence of depression was around 128(64%) had very severe depression, 40(20%) of them had severe depression, 30(15%) had moderate depression and only 2(1%) had mild depression among patients with diabetes mellitus. The calculated Karl Pearson’s Correlation value of r = 0.538 between depression and fasting glucose level shows that moderate positive correlation which was found to be highly statistically significant at p<0.001 level and Correlation value r = 0.401 between depression and post-prandial blood level shows a moderate positive correlation which was found to be statistically significant at p<0.001 level. Conclusion: Thus the study findings clearly reveal that the diabetes mellitus patients prone to develop depression and the awareness programme could not control the prevalence rate of developing depression among diabetes mellitus patients and more focus should be given for the male gender, illiterate, unemployed, mixed diet and poor physical activity among patients with diabetes mellitus.
