Background: Today a little information is known on the lipid spectrum of blood in preeclampsia in pregnant women, at the same time, coverage of this issue could deepen our understanding about changes in the body be-belt with preeclampsia that will justify a more rational therapy of the disease and prevention of complications of gestation. Purpose: To study some parameters of lipid and protein spectrum of blood in pregnant women with preeclampsia. Materials and Methods: Weobserved and studiedblood lipid spectrumin 70 women in II-III trimester of pregnancy; main group consisted of 50 pregnant women with PE light and heavy degree. Preeclampsia was established in 17 (34%) at 28-31 weeks' gestation, in 32 (64%) at 32-36 weeks. The studies were conducted a number of biochemical studies in serum of blood was determined the content of total lipids, cholesterol, triglycerides, β–lipoproteins, phospholipids and albumin.The concentration of substances were determinedby standardized methods using commercial test – systems of firm "Human" on the automatic analyzer "Autohumolyzer F-1". To study the content of lipid components and albumin blood was drawn from the cubital vein in the morning on an empty stomach. Results: The level of total lipids reached to 6.9 ± 0.3 g/l and 8.9 ±0.4 g/l (p < 0.05), that is, 1.4 and 1.8 times higher, the content β-lipoprotein – 4,13 ± 0.1 g/l and 4.83 ± 0.4 g/l (p 0.05), 1.5 and 1.7 times higher than the control group. The concentration of cholesterol amounted to 6.62 ± 0.2 g/l and 8.13 ± 0.3 mmol/l (p < 0.05) or 1.2 and 1.5 times higher than control, the content of triglycerides were 2.6 ± 0.27 and 3.81 ± 0.3 mmol/l (p < 0.05), that is, 2.4 times and 3.5 times higher than the same values in the physiological pregnancy. The level of phospholipids in our patients was evaluated at 1.81 ± 0.1 g/l and 1.41 ± 0.2 g/l (p < 0.05), i.e., 1.5 times and 1.9 times lowerthan the control values. Albumin was equal to 35.2 ± 0.9 g/l and 33.1 ± 1.4 g/l (p < 0.05), 1.2 times and 1.3 times lower than similar values when physiologically flowing pregnancy. Conclusion: Clinicaldata showed a correlation between changes of lipids in the pregnant women with the severity of PE. With the progression of PE, there was a significant increase of the main indicators of lipogram and reducing the level of phospholipids and albumin. The revealed changes in lipid metabolism in pregnant women with preeclampsia may be used as a diagnostic criterion.
