The value of endothelial dysfunction in the genesis of development rheumatoid arthritis

Background: Rheumatoid arthritis (RA) is an autoimmune, systemic disease that affects the joints. In RA, the body’s immune system destroy body’s tissue for a foreign invader. This leads immune system to attack the protective cushion of tissue and fluid between the joints. The result is swelling, stiffness, and pain in the joint. The body’s misfiring immune system also may go after the body’s soft tissues, like cartilage, and organs such as the heart, eyes, and veins. According to the literature, the number of publications on the study of dysfunctional disorders of the endothelium in patients with RA is limited. Methods: Retrospective analysis representing in this article was performed through 68patients with RA who was received inpatient treatment in the Department of Rheumatology 3-clinic Tashkent Medical Academy (TMA) in period from November 2014 to January 2016. Authors analyzed spreading spectrum of endothelium dysfunction degree in RA patients via verified laboratory data. Authors studied the age and gender characteristics of patients with dysfunction that occurred after RA and the degree and severity of endothelial dysfunction. Results: The observation of the dysfunction of endothelial cells of blood vessels was accompanied by impaired synthesis of nitric oxide, which was reflected in a decline in the content of nitric oxide in the blood serum of the surveyed people. In patients with RA anemia syndrome with negative H. pylori infection, this indicator counted to an average of 1.48±0.12 g/ml. In the third group of patients, the studied parameter, has reached a level of 1.24±0.09 g/ml, which is 49% lower than healthy individuals (PL 0.05). The content of Willebrand factor in patients with RA without anemia was, on average, 98.41±7.64, which was 17% higher than in healthy individuals. Conclusion: Endothelial dysfunction is the link between microbes and autoimmune disease. It is possible the mechanism of iron capture by bacteria in the stomach and reduce gastric levels of ascorbic acid, which can lead to the development of anemia.

Aida A. Eshmurzaeva, Abdug’ofir Khodjimetov and Bekhzod Abdullaev
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