Creatine kinase (CK) is an enzyme with three isoforms BB/CK1, MB/CK2 and MM/CK3. Normal range is 22 to 198 U/L (units per liter). Serum creatine kinase (SCK) activity of the skeletal muscle form is sometimes moderately increased in psychiatric patient and may be massively increased as a result of muscle damage and serum creatine kinase activity increases in patients treated with antipsychotics drugs. Raised level of total creatine kinase has been detected in the serum of patients with psychiatric disorders. Different types of psychiatric disorders are present in the Indian population. Bipolar disorder, unipolar disorder, schizophrenia, attention deficit hyperactivity disorder, anxiety disorder, Patterns of belief, language use and perception of reality can become disordered (e.g., delusions, thought disorder, hallucinations). Antipsychotics also known as neuroleptics or major tranquilizers are a class of drugs used in the treatment of psychiatric disorders. There are two categories of antipsychotics: typical antipsychotics and atypical antipsychotics. This review is designed to estimate the serum creatnine kinase on taking antipsychotics in psychiatric patients and thus to find the type of antipsychotics having increased creatine kinase activity. The review shown that the estimation of serum creatine kinase on taking antipsychotics in psychiatric patients.