Effect of sodium valproate in histological features of cerebrum in chick embryos

Valproic acid is an antiepileptic drug prescribed as monotherapy in newly diagnosed cases of Epilepsy. It is also useful in combating generalized Tonic-Clonic Seizures, Partial Seizures, Myoclonic Seizures. It acts by increasing the levels of the Neurotransmitter GABA in the cerebrum. Valproate inhibits sustained repetitive firing induced by depolarization of cortical or spinal cord neurons. It produces small reductions of the low-threshold (T) Calcium current at clinically relevant but slightly higher concentrations then limit sustained repetitive firing. Reducing T currents may contribute to the effectiveness of Valproic acid against partial and tonic–clonic seizures and absence seizures respectively. In vitro, Valproate can stimulate the activity of the GABA synthetic enzyme,Glutamic Acid Decarboxylase and inhibit GABA degradative enzymes,GABA trasaminases . But studies show that they cause defects in the formation of neural tube if used during pregnancy. In the present study fertilized eggs were administered with Sodium Valproate at 24 hours of incubation and the development of Cerebrum was studied after 20 days. The histological and gross features of Cerebrum were identified.

Shabana Sultana, Doshi, M.A., Jayasree, N. and Mrudula Chandrupatla
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Int J Inf Res Rev
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