A simple, sensitive, rapid and selective isocratic reversed phase High Performance Liquid Chromatographic method has been developed for simultaneous estimation of Amlodipine Besylate & Valsartan from pharmaceutical dosage form using a mobile phase consisting mixture of triethylamine Buffer: acetonitrile:Methanol (25:37.5:37.5), (pH adjusted to 3.0 using ortho phosphoric acid) at the flow rate of 1.0 mL/min. A Kromasil C-8 (Intersile250 x 4.6 mm,5 µm.) column was used as stationary phase. The retention time of Amlo and Hydro was 3.97 min. and 2.79 min. respectively. Linearity was observed in the concentration range of 10-80 μg/ml, The recovery studies ascertained the accuracy of the proposed method and the results were validated as per ICH guidelines. The eluent were detected at 230 nm. The Results were found to satisfactory and reproducible. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of Amlodipine Besylate & Valsartan. The method can be used for routine analysis of these drugs in bulk and in formulation.