Design and characterization of divalproex sodium solid dispersion for epilepsy

Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy, bi-polar disorders and prophylaxis of migraine. The major problem with this drug is its poor solubility in biological fluids, which results into poor bioavailability after oral administration. Thus, solid dispersions (SDs) of Divalproex sodium were prepared using Hydroxy propyl methyl cellulose (HPMC), Polyethylene glycol (PEG 6000) and Polyvinyl pyrolidine (PVP K30) to increase its aqueous solubility. SDs of Divalproex sodium was prepared by solvent evaporation method with the ratio of drug and polymers were 1:1. The prepared solid dispersions were subjected for % yield, drug content and infrared (IR) spectroscopic studies and solubility studies. The FTIR results shows absence of significant drug-carrier interaction. In vitro release profiles of all SDs were evaluated and also studied against pure Divalproex sodium. It was observed that faster dissolution was found by solid dispersion containing Drug:HPMC. This may due to hydrophilic nature of the carrier and increase in wettability in solid dispersion. Thus it was concluded that SDs of Divalproex sodium could be beneficial for the treatment of epilepsy with improved bioavailability after oral administration.

Author: 
Subashini Rajaram, Janaani, V., Priya, R., Priyanka, V. and Kalaivani, H.
Journal Name: 
Int J Inf Res Rev
Volume No: 
02
Issue No: 
09
Year: 
2015
Paper Number: 
0508
Select Subjects: 
Select Issue: 
Download PDF: