Objective: To evaluate the effectiveness of medical and surgical therapy in patients of Primary open angle glaucoma. Materials and Methods: Cross-sectional study conducted among 50 patients attended to the ophthalmic department of Government General Hospital, Guntur from November 2004 to November 2006. Results: Primary open angle glaucoma characteristically has an adult onset seen commonly after the age of 40 years and is a bilateral almost symmetrical disease; more common in males. IOP of most of the eyes is between 20 – 30 mm Hg; Cup: Disc ratio in most of the cases is 0.6:1 & 0.7:1 in both sexes. Most common visual field defect in POAG is arcuate scotoma, Superior arcuate scotoma is most common. Most of the eyes showed advanced field loss.