Background: Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. Objective: The aim of this study was to evaluate the association between HP infection and CAD in suspected patients referred for diagnosis coronary angiography. Methodology: 140 patients were divided in two group , in the first group there 70 patients (29 female, 41 male ) having h.pylori positive and coronary heart disease . in the second group , which is arrange as acontrol group there were 70 patients having h,pylori positive with out coronary heart disease . this cross –sectional study referred to heart center Enrolled from January to march 2015 and all of them under went physical examination . in data evaluation age , gender , patient history and bio chemical parameters ( total cholesterol , low density lipoprotein (LDL), H.pylori ,and CRP ) were recorded . The serum HP IgG antibody was measured using ELISa`. While other parameters measured using spectorophotometer (MINDARY. Result: ( mean +,- SD) of serum totalcholestrol ,CRP, LDL in the group which had h.pylori positive and coronary heart disease ( (175.29-47.975) ,( 21.91-17.799), (107.66-44.565) ) while in control group which had h,pylori positive with out coronary heart disease ( (166.00-44.211),(125.47-37.201), (9.13-1.689)) Conclution: this study revelaed the serum of total cholesterol, CRP were significantly increase in group which had h.ylori positive and coronary heart disease. while in other group which had h,pylori positive with out coronary heart disease the serum of LDL was significantly increase .