Irrigation water quality has profound effects on physio-chemical properties of soil, crop productivity, environment and food products. Therefore, an attempt is initiated to evaluate source, availability and quality of tube and canal irrigation of taluka Thull distt: Jacobabad in order to adopt possible best management practices through providing better guidelines to local farmers about quality of tube well and canal irrigation water. The water samples were collected throughout the taluka Thull at distance of 5 square kilometer. Water samples were used to analyze pH, Electrical Conductivity (EC dS m-1), anions such as CO2-, HCO3-, CL-, cations such as (Ca2+, Mg2+, Na+) and Sodium Adsorption Ratio (SAR). Our study revealed that pH was higher than acceptable level in most of the tube well water samples ranged from 7.5 to 9.0. The EC level in tube well water samples were also beyond acceptable level and 75% samples were in hazardous category followed by 25% under marginal category based on the measurement given by WAPDA (1982). Similarly, concentration of anions in tube well water samples were also found under marginal and hazardous categories respectively. Carbonate concentration was observed in tube well water between 1.0 meq/L to 3.2 meq/L. Moreover, Bi-carbonate concentration was recorded between 3.0 meq/L to 8.8 meq/L. Likewise; chloride concentration was recorded between 19.2 meq/L to 60.5 meq/L. In addition, concentration of cations in tube well water samples were also found marginal and hazardous categories respectively. In conclusion, farmers have to take precautionary management practices before using tube well irrigation water.