The high mortality rate for neonatal and premature babies shows that the handling of babies is still rushed. So we need activities to save premature babies from sudden infant death syndrome. This treatment needs to be done from the hospital to the home. This is done until vital organs such as the brain, lungs and heart can function optimally. Premature babies have worse adaptability than term babies. This study aims to analyze the factors that contribute to the success of premature baby care. This research method is observational analytic. Population: mothers who have babies with a history of preterm labor in 2018 totaling 28 respondents. The sampling technique is purposive sampling. The analysis test used in this study is multiple logistic regression. Results: Most of the respondents were aged 20-35 years by 78%, most respondents' education was Primary and Secondary Education by 58%; all respondents housewives by 100%; the parity of respondents is mostly multi gravida at 86%; knowledge of respondents is good at 50%; a history of premature delivery by 93%. Most respondents were positive about the care of premature babies. Baby care methods that use skin contact and who use the same incubator, amounting to 50%. The success of premature baby care for some respondents succeeded in treating premature babies by 64%, which was marked by an increase in body weight of more than 500 grams per month. There is an influence between the history of premature childbirth, knowledge and methods of caring for premature babies on the success of preterm baby care
